SU launch
After intense developments we are proud to announce the launch of our
new Single-Use (SU) filtration and mixing solutions.
Our aim was the development of a disposable filter and a mixing
solution for industries dealing with sterility and hazardous products. The
simplicity of an SU equipment is well appreciated in the industry, but due to a
number of shortcomings there are still many organizations who have major
concerns with this technology. We at DrM, with our roots in the processing
industry put all of our knowledge and expertise together to bring a fresh look
into this by focusing on the process aspects and as a result developed
something uniquely new single-use clarification.
Single-Use Filter FUNDABAC® SU
The value proposition of our FUNDABAC® Single-Use filter is its
ability to reach high throughputs and increased solids capacity while
maintaining high filtrate quality. This is achieved with its multi-cycle
operation: Instead of running the filtration in one single cycle until the SU
bag needs to be disposed, the filtered solids can be discharged from the
filtering elements. They settle in the bottom where they accumulate while the
regenerated filter elements can filter a second, third or any number of
multiple cycles until the complete bag is filled with solids cell
recovery.
A high filtration flux is maintained by small cake thicknesses
(traditional designs rely on thick cakes to increase solids holding capacity
but sacrifice heavily of flux). With the ability to add filter aid, the flows
can be increased further, however, this is not a requirement and is usually decided
during testing. After the batch is processed the heel volume of the bag is
simply squeezed and compacted to a minimum. This is achieved by the unique
design of the filter equipment which allows air pressurization of the cavity
between the SU bag and its housing disposable
filter.
With this patented approach we brought the concept of Single-Use
filtration to a whole new level. It challenges once-through designs and sets
new standards in this emerging industry single-use
agitator.
While many users may first think of the biotech industry as the main
target for such an equipment, its applications may well go beyond this
traditional market. Besides typical downstream processes we had a number of
very specific inquiries for toxic batches where containment of the product is
of highest importance.
FUNDABAC® SU 2L
FUNDAMIX® SU Vibratory Mixer
The FUNDAMIX® Vibromixer has originally found its role in the biotech
industry as its non-rotating agitation allows for a simple and secure sealing
system in sterile applications. For the last 50 years it has provided high
mixing efficiencies at low shear forces and very little energy input. It is a very
mature product which now has been rejuvenated by redesigning the mixing plate
for Single-Use operation single use bioprocessing.
The required changes were minimal as the FUNDAMIX® is ideally suited
for Single-Use applications. However, we came up with some great designs to
make the assembly of the bag in the housing as easy as possible. The drive unit
itself did not require any changes but our patent includes a special docking
mechanism to connect the mixing shaft to the Single-Use mixing plate.
Compared to existing Single-Use agitators the mixing intensity is
significantly improved while at the same time keeping tip speeds well below
what traditional agitators produce. As the amplitude is just a few Millimeter,
the mixing plate can be mounted only a few Centimeter above the bottom of the
Single-Use bag. This reduces liquid heel considerably and hence increases yield
mammalian cell
harvesting.
With the launch of these new products we believe to have two equipment
which enrich the Single-Use industry and provide new opportunities for
operators to look at their process design in a different light. The know-how of
our process and development engineers can further help you enhance process
design when it comes to integration of the equipment, so feel free to contact
us.
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